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    Yes, anabolic steroids are capable of producing depression in certain individuals, due to their lowering of endogenous testosteroneas well as increased synthesis of DHEA. Many of the other synthetic drugs such as amphetamines, cocaine, ecstasy, cannabis, barbiturate, benzodiazepines, and a host of others have similar effects. In people abusing illicit drugs, there are many known risk factors that do not necessarily include high testosterone. A few of these are:1) excessive alcohol consumption, or2) high testosterone levels after exposure to certain environmental or genetic factors in combination with steroids. In addition to this they should discuss their psychological and physical wellbeing.

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    Medical professionals and clinical investigators who wish to conduct blood tests for “steroid tolerance” (such as the FSH, LH/LH ratio and the LH/FT ratio) are advised to consult with a physician. The purpose of this test can be used to determine if an individual has had some form of drug abuse that would result in the production of abnormally low concentrations of FSH, LH/LH ratio or FSH/LH ratio.

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    A patient who is prescribed any form of psychotropic (mind altering/treatable) medication, regardless of the underlying cause is at greater risk of developing hypogonadism. Antidepressants have been shown to reduce hypogonadism by 30% and may be effective in the treatment of hypogonadism. It can be advantageous in some cases, however, in a person who is taking drugs or who is prone to alcohol abuse to see a psychiatrist, not just as a health care professional, but in order to ensure proper health care consultation, to give his/her medications (including their prescription medicine) a few days of additional time to fully clear their system before a new medication was introduced. If the patient is suffering from depression, it is beneficial to have the physician talk to the person about the medications the patient is taking and if appropriate therapy is needed to achieve their goal of improved mental health.

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    Medication can cause depression in some people who have not already been found to be “high- T” or “low” T, and there will be people who will suffer from depression, including those that are taking, or have recently been prescribed, psychostimulants (most notably, amphetamines).[9] These should be treated in order to alleviate the depression rather than to suppress it

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